a-Synuclein(Phospho-Tyr133) Antibody

$454.00

Cat. No.: 38823 Categories: ,

Description

Aliases

NACP; SYN; SYUA; alpha-synuclein;

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: P37840
NCBI Protein: NP_000336.1

Immunogen

Peptide sequence around phosphorylation site of tyrosine 133 (E-G-Y(p)-Q-D) derived from Human a-Synuclein.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB IF Recommended dilution: Predicted MW: 18kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Background / Function

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neuronsKozikowski AP, et al. (2006)ChemMedChem. 1(2):256-66.Jakowec MW,et al.(2001)Dev Neurosci.23(2):91-9.El-Agnaf OM,et al.(1998)FEBS Lett. 440(1-2):67-70.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Tyr133

Additional information

Size

100?l

Certificate of Analysis