ADAM15 Antibody, FITC conjugated

$210.00$377.00

Cat. No.: 44242 Categories: ,

Description

Aliases

Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, Metargidin, ADAM15, MDC15

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q13444

Immunogen

Recombinant human Disintegrin and metalloproteinase domain-containing protein 15 protein (207-452AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Isotype

IgG

Conjugate

FITC

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Cancer

Literature

[1] “Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.”Kraetzschmar J., Lum L., Blobel C.P. J. Biol. Chem. 271:4593-4596(1996) [2] “Expression of a disintegrin-like protein in cultured human vas

Additional information

Size

50μg, 100μg

Certificate of Analysis