ADAMTS4 Antibody, Biotin conjugated

$210.00$377.00

Cat. No.: 39698 Categories: ,

Description

Aliases

ADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

O75173

Immunogen

Recombinant human A disintegrin and metalloproteinase with thrombospondin motifs 4 protein (213-319AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ‘392-Glu-|-Ala-393’ site.

Isotype

IgG

Conjugate

Biotin

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients.”Wainwright S.D., Bondeson J., Hughes C.E. Matrix Biol. 25:317-320(2006). [2]”The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003). [3]”The DNA sequence and biological annotation of human chromosome 1.” Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R. Nature 441:315-321(2006).

Additional information

Size

50μg, 100μg

Certificate of Analysis