Recombinant human ADP-ribosylation factor-like protein 4A protein (2-200AA)
ELISA;Not yet tested in other applications.
Background / Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature”The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.” Hofmann I., Thompson A., Sanderson C.M., Munro S. Curr. Biol. 17:711-716(2006). ”ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.” Bhamidipati A., Lewis S.A., Cowan N.J. J. Cell Biol. 149:1087-1096(1999). ”ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.” Lin C.Y., Huang P.H., Liao W.L., Cheng H.J., Huang C.F., Kuo J.C., Patton W.A., Massenburg D., Moss J., Lee F.J. J. Biol. Chem. 275:37815-37823(1999).