Description
Aliases
BCR; BCR protein; BCR1
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot: P11274
NCBI Protein: NP_004318.3
Immunogen
Peptide sequence around phosphorylation site of tyrosine 177 (P-F-Y(p)-V-N) derived from Human Bcr.
Raised In
Rabbit
Species Reactivity
Human Mouse
Tested Applications
WB IHC Recommended dilution: Predicted MW: 210kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100,
Background / Function
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.Sattler M, et al. Mol Cell Biol. 1999 Nov; 19(11): 7473-7480.Li S et al. EMBO J. 2001 Dec 3; 20(23): 6793-6804.Million RP, et,al. Mol Cell Biol. 2004 Jun; 24(11): 4685-4695.Malcolm A. Meyn, et al. . Biol. Chem., Oct 2006; 281: 30907
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Modification
Phospho-Tyr177
Additional information
| Size | 100?l |
|---|
