Description
Aliases
BH, BLM hydrolase, BMH, BLMH
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q13867
Immunogen
Recombinant human Bleomycin hydrolase protein (1-300AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease.” O’Farrell P.A., Gonzalez F., Zheng W., Johnston S.A., Joshua-Tor L.Structure 7:619-627(1999). [2]Initial characterization of the human central proteome.”Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). [3]Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009).Additional information
| Size | 50μl, 100μl |
|---|
