CaMKII(Phospho-Thr286) Antibody

$454.00

Cat. No.: 38824 Categories: ,

Description

Aliases

CAMKA

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot: Q9UQM7
NCBI Protein: NP_057065.2

Immunogen

Peptide sequence around phosphorylation site of threonine 286 (Q-E-T(p)-V-D) derived from Human CaMKII.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB Recommended dilution: Predicted MW: 50kd, Western blotting: 1:500~1:1000

Background / Function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21): 11232-11237 Hudmon A, et al. J Cell Biol. Author manuscript; available in PMC 2006 May 7 Miller P, et al. PLoS Biol. 2005 Apr; 3(4): e107 Runyan JD, et al. Learn Mem. 2005 Mar; 12(2): 103-110.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Thr286

Additional information

Size

100?l

Certificate of Analysis