Description
Aliases
CBP; CREB binding protein; CREB-binding protein; CREBBP; KAT3A; RSTS
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#：Q92793
Immunogen
A synthesized peptide derived from human CBP
Raised In
Rabbit
Species Reactivity
Human Mouse Rat
Tested Applications
WB IHC IF/ICC Recommended dilution: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
Background / Function
CBP a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1;
Conjugate
Unconjugated
Storage Buffer
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Additional information
| Size | 100?l |
|---|
