Description
Aliases
Ag3, Surface glycoprotein LFA-3, CD58, LFA3
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P19256
Immunogen
Recombinant human Lymphocyte function-associated antigen 3 protein (40-220AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, WB, IHC;Recommended dilution:WB:1:500-2000, IHC:1:20-1:200
Background / Function
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution.”Ikemizu S., Sparks L.M., van der Merwe P.A., Harlos K., Stuart D.I., Jones E.Y., Davis S.J. Proc. Natl. Acad. Sci. U.S.A. 96:4289-4294(1999). [2]Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.” Wang J.H., Smolyar A., Tan K., Liu J.H., Kim M., Sun Z.Y., Wagner G., Reinherz E.L.Cell 97:791-803(1999). [3]Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment.”Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.J. Proteome Res. 5:935-943(2006).Additional information
| Size | 50μl, 100μl |
|---|
