Description
Aliases
COMP, Thrombospondin-5, TSP5, COMP
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P49747
Immunogen
Recombinant human Cartilage oligomeric matrix protein (20-160AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Novel mutation in exon 18 of the cartilage oligomeric matrix protein gene causes a severe pseudoachondroplasia.”Mabuchi A., Haga N., Ikeda T., Manabe N., Ohashi H., Takatori Y., Nakamura K., Ikegawa S.Am. J. Med. Genet. 104:135-139(2001). [2]Double heterozygosity for pseudoachondroplasia and spondyloepiphyseal dysplasia congenita.” Unger S., Koerkkoe J., Krakow D., Lachman R.S., Rimoin D.L., Cohn D.H. Am. J. Med. Genet. 104:140-146(2001). [3]Pseudoachondroplasia due to the substitution of the highly conserved Asp482 by Gly in the seventh calmodulin-like repeat of cartilage oligomeric matrix protein.”Susic S., Ahier J., Cole W.G.Hum. Mutat. Suppl. 1:S125-S127(1998).Additional information
| Size | 50μl, 100μl |
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