Description
Aliases
DHFR
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P00374
Immunogen
Recombinant human Dihydrofolate reductase protein (2-187AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Dihydrofolate reductase
Literature
[1]”Crystal structure of human dihydrofolate reductase complexed with folate.” Oefner C., D’Arcy A., Winkler F.K. Eur. J. Biochem. 174:377-385(1988). [2]”Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.” Anderson D.D., Quintero C.M., Stover P.J. Proc. Natl. Acad. Sci. U.S.A. 108:15163-15168(2011). [3]”Initial characterization of the human central proteome.” Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011).Additional information
| Size | 50μg, 100μg |
|---|
