DNMT3A Antibody, Biotin conjugated

$210.00$377.00

Cat. No.: 41228 Categories: ,

Description

Aliases

DNA methyltransferase HsaIIIA, DNMT3A

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q9Y6K1

Immunogen

Recombinant human DNA (cytosine-5)-methyltransferase 3A protein (680-902AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity

Isotype

IgG

Conjugate

Biotin

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Epigenetics and Nuclear Signaling

Literature

[1]”Cloning, expression and chromosome locations of the human DNMT3 gene family.”Xie S., Wang Z., Okano M., Nogami M., Li Y., He W.-W., Okumura K., Li E.Gene 236:87-95(1999) [2]”A novel Dnmt3a isoform produced from an alternative promoter localizes to eu

Additional information

Size

50μg, 100μg

Certificate of Analysis