4E-BP3, eIF4E-binding protein 3, EIF4EBP3
Recombinant human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)
ELISA;Not yet tested in other applications.
Background / Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team Genome Res. 14:2121-2127(2003). ”4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family.” Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N. J. Biol. Chem. 273:14002-14007(1997).