Description
Aliases
4E-BP3, eIF4E-binding protein 3, EIF4EBP3
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O60516
Immunogen
Recombinant human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team Genome Res. 14:2121-2127(2003). [2]”4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family.” Poulin F., Gingras A.-C., Olsen H., Chevalier S., Sonenberg N. J. Biol. Chem. 273:14002-14007(1997).Additional information
| Size | 50μg, 100μg |
|---|
