ELANE Antibody, FITC conjugated

$210.00$377.00

Cat. No.: 41371 Categories: ,

Description

Aliases

Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P08246

Immunogen

Recombinant human Neutrophil elastase protein (30-267AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Isotype

IgG

Conjugate

FITC

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”Four novel ELANE mutations in patients with congenital neutropenia.” Kurnikova M., Maschan M., Dinova E., Shagina I., Finogenova N., Mamedova E., Polovtseva T., Shagin D., Shcherbina A. Pediatr. Blood Cancer 57:332-335(2011). [2]”Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.” van de Vosse E., Verhard E.M., Tool A.J., de Visser A.W., Kuijpers T.W., Hiemstra P.S., van Dissel J.T. Ann. Hematol. 90:151-158(2011). [3]”Pegfilgrastim in children with severe congenital neutropenia.” Fioredda F., Calvillo M., Lanciotti M., Lanza T., Giunti L., Castagnola E., Lorenzi I., Tonelli R., Ghezzi P., Dufour C.Pediatr. Blood Cancer 54:465-467(2010).

Additional information

Size

50μg, 100μg

Certificate of Analysis