Description
Aliases
Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P08246
Immunogen
Recombinant human Neutrophil elastase protein (30-267AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Four novel ELANE mutations in patients with congenital neutropenia.” Kurnikova M., Maschan M., Dinova E., Shagina I., Finogenova N., Mamedova E., Polovtseva T., Shagin D., Shcherbina A. Pediatr. Blood Cancer 57:332-335(2011). [2]”Severe congenital neutropenia in a multigenerational family with a novel neutrophil elastase (ELANE) mutation.” van de Vosse E., Verhard E.M., Tool A.J., de Visser A.W., Kuijpers T.W., Hiemstra P.S., van Dissel J.T. Ann. Hematol. 90:151-158(2011). [3]”Pegfilgrastim in children with severe congenital neutropenia.” Fioredda F., Calvillo M., Lanciotti M., Lanza T., Giunti L., Castagnola E., Lorenzi I., Tonelli R., Ghezzi P., Dufour C.Pediatr. Blood Cancer 54:465-467(2010).Additional information
| Size | 50μg, 100μg |
|---|
