EXO1 Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

Exonuclease 1, hExo1, Exonuclease I, hExoI, EXO1, EXOI, HEX1

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q9UQ84

Immunogen

Recombinant human Exonuclease 1 protein (301-600AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

5′->3′ double-stranded DNA exonuclease which may also possess a cryptic 3′->5′ double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5′ or 3′ to the mismatch. Also exhibits endonuclease activity against 5′-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5′-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

>95%,Protein G purified

Additional information

Size

50μg, 100μg

Certificate of Analysis