Exonuclease 1, hExo1, Exonuclease I, hExoI, EXO1, EXOI, HEX1
Recombinant human Exonuclease 1 protein (301-600AA)
ELISA, WB, IHC;Not yet tested in other applications.
Background / Function
5′->3′ double-stranded DNA exonuclease which may also possess a cryptic 3′->5′ double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5′ or 3′ to the mismatch. Also exhibits endonuclease activity against 5′-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5′-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
>95%,Protein G purified