Description
Aliases
EYA2, EAB1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O00167
Immunogen
Recombinant human Eyes absent homolog 2 protein (1-514AA)
Raised In
Rabbit
Species Reactivity
human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ‘Tyr-142’ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ‘Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Epigenetics and Nuclear Signaling
Literature
[1]”Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.” Patrick A.N., Cabrera J.H., Smith A.L., Chen X.S., Ford H.L., Zhao R.Nat. Struct. Mol. Biol. 20:447-453(2013) .Additional information
Size | 50μg, 100μg |
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