EYA2 Antibody

$210.00$377.00

Cat. No.: 41513 Categories: ,

Description

Aliases

EYA2, EAB1

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

O00167

Immunogen

Recombinant human Eyes absent homolog 2 protein (1-514AA)

Raised In

Rabbit

Species Reactivity

human

Tested Applications

ELISA, IHC;Recommended dilution:IHC:1:20-1:200

Background / Function

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates ‘Tyr-142’ of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. ‘Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Epigenetics and Nuclear Signaling

Literature

[1]”Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.” Patrick A.N., Cabrera J.H., Smith A.L., Chen X.S., Ford H.L., Zhao R.Nat. Struct. Mol. Biol. 20:447-453(2013) .

Additional information

Size

50μg, 100μg

Certificate of Analysis