Description
Aliases
Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL, APL, FasL ICD, SPPL2A-processed FasL form, SPA, FASLG, APT1LG1, CD95L, FASL, TNFSF6
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P48023
Immunogen
Recombinant human Tumor necrosis factor ligand superfamily member 6 protein (103-281AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Apoptosis
Literature
[1]”Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.”Voss M., Lettau M., Janssen O.BMC Immunol. 10:53-53(2009).Additional information
| Size | 50μg, 100μg |
|---|
