Description
Aliases
Regulator of Fas-induced apoptosis Toso, Faim3, Toso
Antibody Type
Polyclonal Antibody
Species
Mouse
Uniprot ID
A1KXC4
Immunogen
Recombinant mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Fas apoptotic inhibitory molecule 3
Literature
[1]”The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team Genome Res. 14:2121-2127(2004). [2]”The transcriptional landscape of the mammalian genome.” Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list Hayashizaki Y. Science 309:1559-1563(2005) . [3]Song Y., Jacob C.O. Submitted (JAN-2003).Additional information
| Size | 50μg, 100μg |
|---|
