FFAR1 Antibody, Biotin conjugated

Conjugate: Biotin. Product Type: Polyclonal Antibody. Clonality: Polyclonal. Isotype: IgG. Form: Liquid. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Raised in: Rabbit. Aliases: FFA1R antibody; FFAR 1 antibody; Ffar1 antibody; FFAR1_HUMAN antibody; Free fatty acid receptor 1 antibody; G protein coupled receptor 40 antibody; G-protein coupled receptor 40 antibody; GPCR40 antibody; GPR 40 antibody; GPR40 antibody. Immunogen Species: Homo sapiens (Human). UniProt ID: O14842. Immunogen: Recombinant Human Free fatty acid receptor 1 protein (143-178AA). Species Reactivity: Human. Tested Applications: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200. Background: G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Purification Method: >95%, Protein G purified. Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Target Names: FFAR1.