SNT-1; SNT2; FGFR signalling adaptor;
NCBI Gene#: 10818;
Peptide sequence around phosphorylation site of tyrosine 436(L-N-Y(p)-I-Q) derived from Human FRS2 .
WB IHC Recommended dilution: Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background / Function
FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways. Xu H., J. Biol. Chem. 273:17987-17990(1998).Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).Dhalluin C., Mol. Cell 6:921-929(2000).
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.