Description
Aliases
DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P24522
Immunogen
Recombinant humanGrowth arrest and DNA damage-inducible protein GADD45 alpha protein (1-165AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.”Sanchez R., Pantoja-Uceda D., Prieto J., Diercks T., Marcaida M.J., Montoya G., Campos-Olivas R., Blanco F.J.J. Biol. Chem. 285:22196-22201(2010). [2]CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.”Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.J. Biol. Chem. 278:28079-28088(2003)Additional information
| Size | 50μg, 100μg |
|---|
