GADD45A Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P24522

Immunogen

Recombinant humanGrowth arrest and DNA damage-inducible protein GADD45 alpha protein (1-165AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.”Sanchez R., Pantoja-Uceda D., Prieto J., Diercks T., Marcaida M.J., Montoya G., Campos-Olivas R., Blanco F.J.J. Biol. Chem. 285:22196-22201(2010). [2]CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.”Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.J. Biol. Chem. 278:28079-28088(2003)

Additional information

Size

50μg, 100μg

Certificate of Analysis