Description
Aliases
Endothelial transcription factor GATA-2, GATA-binding protein 2, GATA2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P23769
Immunogen
Recombinant human Endothelial transcription factor GATA-2 protein (1-300AA)
Raised In
Rabbit
Species Reactivity
Human,Mouse
Tested Applications
ELISA, WB, IHC;Recommended dilution:WB:1:500-1000, IHC:1:20-1:200
Background / Function
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5′-AGATAG-3′.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.” Hahn C.N., Chong C.E., Carmichael C.L., Wilkins E.J., Brautigan P.J., Li X.C., Babic M., Lin M., Carmagnac A., Lee Y.K., Kok C.H., Gagliardi L., Friend K.L., Ekert P.G., Butcher C.M., Brown A.L., Lewis I.D., To L.B. Scott H.S.Nat. Genet. 43:1012-1017(2011). [2]Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).”Ostergaard P., Simpson M.A., Connell F.C., Steward C.G., Brice G., Woollard W.J., Dafou D., Kilo T., Smithson S., Lunt P., Murday V.A., Hodgson S., Keenan R., Pilz D.T., Martinez-Corral I., Makinen T., Mortimer P.S., Jeffery S., Trembath R.C., Mansour S.Nat. Genet. 43:929-931(2011). [3]Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.”Hsu A.P., Sampaio E.P., Khan J., Calvo K.R., Lemieux J.E., Patel S.Y., Frucht D.M., Vinh D.C., Auth R.D., Freeman A.F., Olivier K.N., Uzel G., Zerbe C.S., Spalding C., Pittaluga S., Raffeld M., Kuhns D.B., Ding L. Holland S.M.Blood 118:2653-2655(2011).Additional information
| Size | 50μl, 100μl |
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