GIF Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

Intrinsic factor, IF, INF, IFMH, GIF

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P27352

Immunogen

Recombinant human Gastric intrinsic factor protein (19-417AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene.” Tanner S.M., Li Z., Perko J.D., Oener C., Cetin M., Altay C., Yurtsever Z., David K.L., Faivre L., Ismail E.A., Graesbeck R., de la Chapelle A. Proc. Natl. Acad. Sci. U.S.A. 102:4130-4133(2005). [2]”A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency.” Gordon M.M., Brada N., Remacha A., Badell I., del Rio E., Baiget M., Santer R., Quadros E.V., Rothenberg S.P., Alpers D.H. Hum. Mutat. 23:85-91(2004). [3]”Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.”Andersen C.B., Madsen M., Storm T., Moestrup S.K., Andersen G.R. Nature 464:445-448(2010).

Additional information

Size

50μg, 100μg

Certificate of Analysis