GRIA3 Antibody

$210.00$377.00

Cat. No.: 42117 Categories: ,

Description

Aliases

GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3, Glutamate receptor ionotropic, AMPA 3, GluA3, GLUR3, GLURC, GRIA3

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P42263

Immunogen

Recombinant human Glutamate receptor 3 protein (151-250AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC;Recommended dilution:IHC:1:20-1:200

Background / Function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Literature

[1]”Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.” Wu Y., Arai A.C., Rumbaugh G., Srivastava A.K., Turner G., Hayashi T., Suzuki E., Jiang Y., Zhang L., Rodriguez J., Boyle J., Tarpey P., Raymond F.L., Nevelsteen J., Froyen G., Stratton M., Futreal A., Gecz J. Wang T. Proc. Natl. Acad. Sci. U.S.A. 104:18163-18168(2006). [2]”Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.” Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S. Neuron 68:1082-1096(2009). [3]”Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.” Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y. Am. J. Med. Genet. 90:69-71(1999).

Additional information

Size

50μg, 100μg

Certificate of Analysis