GRK2 Antibody, HRP conjugated

Description

Aliases

G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P25098

Immunogen

Recombinant human Beta-adrenergic receptor kinase 1 protein (2-221AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Neuroscience

Literature

[1] cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.FEBS Lett. 283:122-126(1991) [2] High expression of beta-adrenergic receptor kinase in

Additional information

Size	50μg, 100μg