Description
Aliases
Granulins, PEPI, Glycoprotein of 88 Kda, Progranulin, Granulin G, Granulin F, Granulin B, Granulin A, Granulin C, Granulin D, Granulin E, GRN
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P28799
Immunogen
Recombinant human Granulins protein (20-310AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]A thorough assessment of benign genetic variability in GRN and MAPT.”Guerreiro R.J., Washecka N., Hardy J., Singleton A.Hum. Mutat. 31:E1126-E1140(2010). [2]Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.” Mukherjee O., Wang J., Gitcho M., Chakraverty S., Taylor-Reinwald L., Shears S., Kauwe J.S.K., Norton J., Levitch D., Bigio E.H., Hatanpaa K.J., White C.L., Morris J.C., Cairns N.J., Goate A.Hum. Mutat. 29:512-521(2008). [3]HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin.”Mukherjee O., Pastor P., Cairns N.J., Chakraverty S., Kauwe J.S.K., Shears S., Behrens M.I., Budde J., Hinrichs A.L., Norton J., Levitch D., Taylor-Reinwald L., Gitcho M., Tu P.-H., Tenenholz Grinberg L., Liscic R.M., Armendariz J., Morris J.C., Goate A.M.Ann. Neurol. 60:314-322(2006).Additional information
| Size | 50μl, 100μl |
|---|
