GSDMA Antibody, FITC conjugated

Conjugate: FITC. Product Type: Polyclonal Antibody. Clonality: Polyclonal. Isotype: IgG. Form: Liquid. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Raised in: Rabbit. Aliases: GSDMA antibody; GSDM antibody; GSDM1 antibody; FKSG9Gasdermin-A antibody; Gasdermin-1 antibody. Immunogen Species: Homo sapiens (Human). UniProt ID: Q96QA5. Immunogen: Recombinant Human Gasdermin-A protein (64-172AA). Species Reactivity: Human. Tested Applications: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200. Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). Purification Method: >95%, Protein G purified. Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Target Names: GSDMA.