Gzma Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

Granzyme A (EC:3.4.21.78), Gzma, Ctla-3, Ctla3, Mtsp-1, Autocrine thymic lymphoma granzyme-like serine protease, CTLA-3, Fragmentin-1, T cell-specific serine protease 1, TSP-1

Antibody Type

Polyclonal Antibody

Species

Mouse

Uniprot ID

P11032

Immunogen

Recombinant mouse Granzyme A protein (29-260AA)

Raised In

Rabbit

Species Reactivity

Mouse

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after ‘Lys-31’ and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after ‘Lys-189’, which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Additional information

Size

50μg, 100μg

Certificate of Analysis