Description
Aliases
Granzyme A (EC:3.4.21.78), Gzma, Ctla-3, Ctla3, Mtsp-1, Autocrine thymic lymphoma granzyme-like serine protease, CTLA-3, Fragmentin-1, T cell-specific serine protease 1, TSP-1
Antibody Type
Polyclonal Antibody
Species
Mouse
Uniprot ID
P11032
Immunogen
Recombinant mouse Granzyme A protein (29-260AA)
Raised In
Rabbit
Species Reactivity
Mouse
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after ‘Lys-31’ and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after ‘Lys-189’, which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity).
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Additional information
| Size | 50μg, 100μg |
|---|
