Has2 Antibody, FITC conjugated

$210.00$377.00

Cat. No.: 42235 Categories: ,

Description

Aliases

Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, Has2

Antibody Type

Polyclonal Antibody

Species

Mouse

Uniprot ID

P70312

Immunogen

Recombinant mouse Hyaluronan synthase 2 protein (67-374AA)

Raised In

Rabbit

Species Reactivity

mouse

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.

Isotype

IgG

Conjugate

FITC

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Others

Literature

[1]”Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.” Camenisch T.D., Spicer A.P., Brehm-Gibson T., Biesterfeldt J., Augustine M.L., Calabro A. Jr.,

Additional information

Size

50μg, 100μg

Certificate of Analysis