Description
Aliases
HDAC8, HDACL1, CDA07
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9BY41
Immunogen
Recombinant human Histone deacetylase 8 protein (1-377AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
Isotype
IgG
Conjugate
HRP
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Literature
[1]”Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.” Dowling D.P., Gantt S.L., Gattis S.G., Fierke C.A., Christianson D.W.Biochemistry 47:13554-13563(2008) . [2]”Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.” Vannini A., Volpari C., Gallinari P., Jones P., Mattu M., Carfi A., De Francesco R., Steinkuehler C., Di Marco S. EMBO Rep. 8:879-884(2007). [3]”Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.” Somoza J.R., Skene R.J., Katz B.A., Mol C., Ho J.D., Jennings A.J., Luong C., Arvai A., Buggy J.J., Chi E., Tang J., Sang B.-C., Verner E., Wynands R., Leahy E.M., Dougan D.R., Snell G., Navre M. expand/collapse author list Tari L.W. Structure 12:1325-1334(2004).Additional information
| Size | 50μg, 100μg |
|---|
