Description
Aliases
HIP-1, Huntingtin-interacting protein I, HIP-I
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O00291
Immunogen
Recombinant human Huntingtin-interacting protein 1 protein (410-690AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, WB, IHC;Recommended dilution:WB:1:200-1000, IHC:1:20-1:200
Background / Function
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity purified
Literature
[1]Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).” Niu Q., Ybe J.A.J. Mol. Biol. 375:1197-1205(2008). [2]Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.”Ybe J.A., Mishra S., Helms S., Nix J.J. Mol. Biol. 367:8-15(2007).Additional information
| Size | 50μl, 100μl |
|---|
