IL22RA1 Antibody, Biotin conjugated

$220.50$395.85

Cat. No.: 53217 Categories: ,

Description

Aliases

IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11, IL22R, IL22RA1

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q8N6P7

Immunogen

Recombinant human Interleukin-22 receptor subunit alpha-1 protein (250-573AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Isotype

IgG

Conjugate

Biotin

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Modification

Interleukin-22 receptor subunit alpha-1

Literature

[1]”Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.” Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I. FEBS Lett. 582:2985-2992(2008). [2]”The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy.” Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M., Iversen L., Deleuran B. Cytokine 41:16-23(2008). [3]”Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor.” Ramanathan M. Jr., Spannhake E.W., Lane A.P. Laryngoscope 117:1839-1843(2007).

Additional information

Size

100μg, 50μg

Certificate of Analysis