Description
Aliases
IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11, IL22R, IL22RA1
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q8N6P7
Immunogen
Recombinant human Interleukin-22 receptor subunit alpha-1 protein (250-573AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Interleukin-22 receptor subunit alpha-1
Literature
[1]”Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.” Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I. FEBS Lett. 582:2985-2992(2008). [2]”The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy.” Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M., Iversen L., Deleuran B. Cytokine 41:16-23(2008). [3]”Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor.” Ramanathan M. Jr., Spannhake E.W., Lane A.P. Laryngoscope 117:1839-1843(2007).Additional information
Size | 100μg, 50μg |
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