Description
Aliases
59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q13418
Immunogen
Recombinant human Integrin-linked protein kinase protein (1-228AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Modification
Integrin-linked protein kinase protein
Research
Signal Transduction
Literature
[1] “Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.”Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S.Nature 379:91-96(1996) [2] “ClAdditional information
Size | 50μg, 100μg |
---|