ILK Antibody, HRP conjugated

$210.00$377.00

Description

Aliases

59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

Q13418

Immunogen

Recombinant human Integrin-linked protein kinase protein (1-228AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA;Not yet tested in other applications.

Background / Function

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Isotype

IgG

Conjugate

HRP

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Modification

Integrin-linked protein kinase protein

Research

Signal Transduction

Literature

[1] “Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase.”Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S.Nature 379:91-96(1996) [2] “Cl

Additional information

Size

50μg, 100μg

Certificate of Analysis