LRP8 Antibody

Aliases Low-density lipoprotein receptor-related protein 8, LRP-8, Apolipoprotein E receptor 2, LRP8, APOER2 Antibody Type Polyclonal Species Human Uniprot ID Q14114 Immunogen Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA) Raised In Rabbit Species Reactivity Human Tested Applications ELISA, WB, IF;Recommended dilution:WB:1:500-1:5000, IF:1:50-1:200 Background / Function Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Isotype IgG Conjugate Unconjugated Storage Buffer Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form Liquid Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze. Purity >95%,Protein G purified Modification Low-density lipoprotein receptor-related protein 8