MAPKAPK2 (Phospho-Ser272) Antibody

$454.00

Cat. No.: 38929 Categories: ,

Description

Aliases

MAPK2; MAPKAPK2; RPS6KC1;

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#: P49137;
NCBI Gene#: 9261;
N

Immunogen

Peptide sequence around phosphorylation site of Serine 272(A-I-S(p)-P-G) derived from Human MAPKAPK2.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB IHC Recommended dilution: Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Background / Function

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.Zu Y.-L., Biochem. Biophys. Res. Commun. 200-1118-1124(1994).The MGC Project Team; Genome Res. 14:2121-2127(2004).Stokoe D., Biochem. J. 296:843-849(1993).

Conjugate

Unconjugated

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Ser272

Additional information

Size

100?l

Certificate of Analysis