Description
Aliases
Triplet-expansion RNA-binding protein, MBNL1, EXP, KIAA0428, MBNL
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
Q9NR56
Immunogen
Recombinant human Muscleblind-like protein 1 protein (1-382AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5′-YGCU(U/G)Y-3’consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Isotype
IgG
Conjugate
Biotin
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Transcription
Literature
[1]”Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1.”Teplova M., Patel D.J.Nat. Struct. Mol. Biol. 15:1343-1351(2008). [2]”Initial characterization of the human central proteome.”Burkard T.R., PlanyavAdditional information
| Size | 50μg, 100μg |
|---|
