MDM4 (Phospho-Ser367) Antibody

$476.70

Cat. No.: 38956 Categories: ,

Description

Aliases

double minute 4 protein; Mdm2-like p53-binding protein; MDMX; p53-binding protein Mdm4

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#:O15151;
NCBI Gene#:4194

Immunogen

Peptide sequence around phosphorylation site of serine 367 (T-I-S(p)-A-P) derived from Human MDM4.

Raised In

Rabbit

Species Reactivity

Human Mouse Rat

Tested Applications

WB IHC Recommended dilution: Western blotting: 1:500~1:3000, Immunohistochemistry: 1:50~1:100,

Background / Function

Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Conjugate

Unconjugated

Storage Buffer

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Modification

Phospho-Ser367

Additional information

Size

100μl

Certificate of Analysis