Description
Aliases
KBF1; NF-kB1; NFkappaB
Antibody Type
Polyclonal Antibody
Uniprot ID
Swiss-Prot#: P19838; NCBI Gene#: 4790
Immunogen
Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NFκB-p105.
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
IHC IF Recommended dilution: Immunohistochemistry:1:50~1:100, Immunofluorescence:1:100~1:200
Background / Function
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
Conjugate
Unconjugated
Storage Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Modification
Phospho-Ser893
Additional information
Size | 100μl |
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