NFκB-p105(Phospho-Ser893) Antibody

$476.70

Cat. No.: 38873 Categories: ,

Description

Aliases

KBF1; NF-kB1; NFkappaB

Antibody Type

Polyclonal Antibody

Uniprot ID

Swiss-Prot#: P19838; NCBI Gene#: 4790

Immunogen

Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NFκB-p105.

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

IHC IF Recommended dilution: Immunohistochemistry:1:50~1:100, Immunofluorescence:1:100~1:200

Background / Function

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Conjugate

Unconjugated

Storage Buffer

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Modification

Phospho-Ser893

Additional information

Size

100μl

Certificate of Analysis