NPC2 Antibody

$210.00$377.00

Cat. No.: 43538 Categories: ,

Description

Aliases

Epididymal secretory protein E1, NPC2, HE1, Human epididymis-specific protein 1, He1, Niemann-Pick disease type C2 protein

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

P61916

Immunogen

Recombinant human Epididymal secretory protein E1 protein (20-151AA)

Raised In

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC;Not yet tested in other applications.

Background / Function

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ‘tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Additional information

Size

50μg, 100μg

Certificate of Analysis