Description
Aliases
Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
P13056
Immunogen
Recombinant human Nuclear receptor subfamily 2 group C member 1 protein (1-240AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5′-AGGTCA-3′ half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity Purified
Literature
[1]Complete sequencing and characterization of 21,243 full-length human cDNAs.”Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004). [2]Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.”Hu Y.C., Shyr C.R., Che W., Mu X.M., Kim E., Chang C.J. Biol. Chem. 277:33571-33579(2002). [3]Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.” Lin Y.L., Wang Y.H., Lee H.J.Biochem. Biophys. Res. Commun. 350:430-436(2006).Additional information
| Size | 50μl, 100μl |
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