Description
Aliases
Vascular endothelial cell growth factor 165 receptor, NRP1, NRP, VEGF165R
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O14786
Immunogen
Recombinant human Neuropilin-1 protein (684-923AA)
Raised In
Rabbit
Species Reactivity
Human
Tested Applications
ELISA, IHC;Recommended dilution:IHC:1:20-1:200
Background / Function
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity purified
Literature
[1]Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.” Appleton B.A., Wu P., Maloney J., Yin J., Liang W.C., Stawicki S., Mortara K., Bowman K.K., Elliott J.M., Desmarais W., Bazan J.F., Bagri A., Tessier-Lavigne M., Koch A.W., Wu Y., Watts R.J., Wiesmann C.EMBO J. 26:4902-4912(2007). [2]Crystal structure of the human neuropilin-1 b1 domain.”Lee C.C., Kreusch A., McMullan D., Ng K., Spraggon G.Structure 11:99-108(2003).Additional information
| Size | 50μl, 100μl |
|---|
