Aliases
ORC4, ORC4L
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O43929
Immunogen
Recombinant human Origin recognition complex subunit 4 protein (1-436AA)
Raised In
Rabbit
Species Reactivity
human
Tested Applications
ELISA;Not yet tested in other applications.
Background / Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Isotype
IgG
Conjugate
FITC
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Research
Transcription
Literature
[1]”Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.”Guernsey D.L., Matsuoka M., Jiang H., Evans S., Macgillivray C., Nightingale M., Perry S., Ferguson M., LeBlanc M., Paquette J., Patry L., Rideout A.L., Thomas
