PARN Antibody

$210.00$377.00

Cat. No.: 43738 Categories: ,

Description

Aliases

PAM16 MAGMAS, TIM16, TIMM16 CGI-136

Antibody Type

Polyclonal Antibody

Species

Human

Uniprot ID

O95453

Immunogen

Recombinant human Poly(A)-specific ribonuclease PARN protein (1-639AA)

Raised In

Rabbit

Species Reactivity

Human;Other species are not tested.Please decide the specificity by homology

Tested Applications

ELISA, WB, IHC

Background / Function

3′-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3′-end poly(A) tail and the 5′-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3′-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

Isotype

IgG

Conjugate

Unconjugated

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

liquid

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.

Purity

Caprylic Acid Ammonium Sulfate Precipitation purified

Research

Transcription

Literature

[1]The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.Koerner C.G., Wormington M., Muckenthaler M., Schneider S., Dehlin E., Wahle E.EMBO J. 17:5427-5437(1998) [2]Complete sequencing and

Additional information

Size

50μg, 100μg

Certificate of Analysis