Description
Aliases
Paired box protein Pax-4, PAX4
Antibody Type
Polyclonal Antibody
Species
Human
Uniprot ID
O43316
Immunogen
Recombinant human Paired box protein Pax-4 protein (50-200AA)
Raised In
Rabbit
Species Reactivity
Human,mouse
Tested Applications
ELISA, WB, IHC;Recommended dilution:WB:1:500-1:2000, IHC:1:20-1:200
Background / Function
Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.
Isotype
IgG
Conjugate
Unconjugated
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Purity
Antigen Affinity purified
Literature
[1]PAX4 mutations in Thais with maturity onset diabetes of the young.”Plengvidhya N., Kooptiwut S., Songtawee N., Doi A., Furuta H., Nishi M., Nanjo K., Tantibhedhyangkul W., Boonyasrisawat W., Yenchitsomanus P.-T., Doria A., Banchuin N.J. Clin. Endocrinol. Metab. 92:2821-2826(2007). [2]Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity.”Biason-Lauber A., Boehm B., Lang-Muritano M., Gauthier B.R., Brun T., Wollheim C.B., Schoenle E.J.Diabetologia 48:900-905(2005). [3]PAX4 gene variations predispose to ketosis-prone diabetes.”Mauvais-Jarvis F., Smith S.B., Le May C., Leal S.M., Gautier J.-F., Molokhia M., Riveline J.-P., Rajan A.S., Kevorkian J.-P., Zhang S., Vexiau P., German M.S., Vaisse C.Hum. Mol. Genet. 13:3151-3159(2004).Additional information
| Size | 50μl, 100μl |
|---|
