KPCD1; PKC-mu; PKCM; PKD; PRKCM
NCBI Protein: NP_002733.2
Peptide sequence around phosphorylation site of serine 910 (R-V-S(p)-I-L) derived from Human PKD/PKCm.
Human Mouse Rat
WB IF Recommended dilution: Predicted MW: 115kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Background / Function
Converts transient diacylglycerol. (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.Matthews SA, et al. J Biol Chem 1999 Sep; 274(37): 26543-26549Brandlin I, et al. J Biol Chem 2002 Feb; 277(8): 6490-6496Storz P, et al. Mol Pharmacol 2004 Oct; 66(4): 870-879
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.