PPP1R3B Antibody

Conjugate: Non-conjugated. Product Type: Polyclonal Antibody. Clonality: Polyclonal. Raised in: Rabbit. Isotype: IgG. Purification Method: >95%, Protein G purified. Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Form: Liquid. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Aliases: FLJ14005 antibody; FLJ34675 antibody; GL antibody; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody; Hepatic glycogen targeting subunit G(L) antibody; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody; PP1 subunit R4 antibody; Ppp1r3b antibody; PPP1R4 antibody; PPR3B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody; Protein phosphatase 1 regulatory subunit 3B antibody; Protein phosphatase 1 regulatory subunit 4 antibody; Protein phosphatase 1 subunit 4 antibody; Protein phosphatase 1 subunit GL antibody; PTG antibody; R4 antibody. Immunogen Species: Homo sapiens (Human). UniProt ID: Q86XI6. Immunogen: Recombinant Human Protein phosphatase 1 regulatory subunit 3B protein (1-285AA). Species Reactivity: Human, Mouse, Rat. Tested Applications: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200. Background: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. Target: PPP1R3B.